DROTIWEL

Drotaverine+Mefenamic Acid is used in the treatment of abdominal pain.

Nausea, Vomiting, Diarrhea, Dryness in mouth, Heartburn, Vertigo, Insomnia (difficulty in sleeping), Hypotension (low blood pressure), Fast heart rate, Sweating, Constipation, Increased liver enzymes, Increased white blood cell count (eosinophils), Decreased white blood cell count (lymphocytes), Low blood platelets, Purpura, Agranulocytosis (deficiency of granulocytes in the blood), Breathlessness, Ringing in ear, Abdominal pain, Flatulence, Indigestion, Stomach inflammation, Confusion, Depression

As prescribed by doctor

Drotaverine + Mefenamic Acid is a combination of two medicines: Drotaverine and Mefenamic Acid, which relieves abdominal pain and cramps. Drotaverine is an anti-spasmodic medicine which relieves contractions (spasms) associated with smooth muscles in the abdomen. Mefenamic Acid is a non-steroidal anti-inflammatory drug (NSAID). It works by blocking the release of certain chemical messengers that cause abdominal pain and inflammation (swelling).
Drotaverine is a selective inhibitor of phosphodiesterase 4 (PDE4), which is an enzyme responsible for the degradation of cyclic adenosine monophosphate (cAMP). Inhibition of PDE4 leads to elevated levels of cAMP, leading to smooth muscle relaxation. Recent research showed that low levels of cAMP have been associated with brain tumorigenesis, leading to the investigation of PDE4 inhibitors as potential anticancer agents

Drotaverine + Mefenamic Acid helps relieve abdominal pain.
Take it with food to prevent an upset stomach.
It may cause dizziness and sleepiness. Don't drive or do anything that requires mental focus until you know how it affects you.
Avoid consuming alcohol while taking Drotaverine + Mefenamic Acid as it can cause excessive drowsiness and increase your risk of stomach problems.

If you have missed giving any dose of this medicine, then give it as soon as you remember. If it's already time for the next dose then skip the missed dose and follow the regular dosing schedule. Follow the dosing schedule regularly & take this medicine at regular intervals.

1. Bolaji OO, Onyeji CO, Ogundaini AO, Olugbade TA, Ogunbona FA: Pharmacokinetics and bioavailability of drotaverine in humans. Eur J Drug Metab Pharmacokinet. 1996 Jul-Sep;21(3):217-21. [Article]
2. Rai RR, Dwivedi M, Kumar N: Efficacy and safety of drotaverine hydrochloride in irritable bowel syndrome: a randomized double-blind placebo-controlled study. Saudi J Gastroenterol. 2014 Nov-Dec;20(6):378-82. doi: 10.4103/1319-3767.145331. [Article]
3. Tomaszewski D, Balkota M: Intramuscular Administration of Drotaverine Hydrochloride Decreases Both Incidence of Urinary Retention and Time to Micturition in Orthopedic Patients under Spinal Anesthesia: A Single Blinded Randomized Study. Biomed Res Int. 2015;2015:926953. doi: 10.1155/2015/926953. Epub 2015 Jun 21.

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