NICPRAZOLE-LS

Description

It works by reducing the amount of acid in the stomach which helps in the relief of acid-related indigestion and ulcers.

Levosulpiride+Rabeprazole is used in the treatment of gastroesophageal reflux disease (acid reflux), intestinal ulcers and irritable bowel syndrome.

Nausea, Diarrhea, Flatulence, Headache, Dizziness, Weakness, Vomiting, Abdominal pain, Drowsiness, Absence of menstrual periods, Breast enlargement in male, Unusual production of breast milk in women and men, Altered libido

As prescribed by doctor

Rabeprazole belongs to a class of antisecretory compounds (substituted benzimidazole proton-pump inhibitors) that do not exhibit anticholinergic or histamine H2-receptor antagonist properties, but suppress gastric acid secretion by inhibiting the gastric H+/K+ATPase (hydrogen-potassium adenosine triphosphatase) at the secretory surface of the gastric parietal cell. Because this enzyme is regarded as the acid (proton) pump within the parietal cell, rabeprazole has been characterized as a gastric proton-pump inhibitor. Rabeprazole blocks the final step of gastric acid secretion. In gastric parietal cells, rabeprazole is protonated, accumulates, and is transformed to an active sulfenamide. When studied in vitro, rabeprazole is chemically activated at pH 1.2 with a half-life of 78 seconds.

• 1. Acemetacin may decrease the excretion rate of Rabeprazole which could result in a higher serum level.


• 2. The serum concentration of Acenocoumarol can be increased when it is combined with Rabeprazole.


• 3. Acetaminophen may decrease the excretion rate of Rabeprazole which could result in a higher serum level.


• 4. Acetazolamide may increase the excretion rate of Rabeprazole which could result in a lower serum level and potentially a reduction in efficacy.


• 5. Acetylsalicylic acid may decrease the excretion rate of Rabeprazole which could result in a higher serum level.

Take it one hour before the meal, preferably in the morning. It is a well-tolerated medicine and provides relief for a long time. Inform your doctor if you get watery diarrhea, fever or stomach pain that does not go away.

If you have missed giving any dose of this medicine, then give it as soon as you remember. If it's already time for the next dose then skip the missed dose and follow the regular dosing schedule. Follow the dosing schedule regularly & take this medicine at regular intervals.

• 1. Langtry HD, Markham A: Rabeprazole: a review of its use in acid-related gastrointestinal disorders. Drugs. 1999 Oct;58(4):725-42. [Article]
• 2. Carswell CI, Goa KL: Rabeprazole: an update of its use in acid-related disorders. Drugs. 2001;61(15):2327-56. [Article]
• 3. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [Article]