PANTODIL (TABLETS)

Description

Pantoprazole 40mg is a tablet formulation containing a proton pump inhibitor (PPI). This medication effectively reduces stomach acid production by inhibiting the action of proton pumps in the stomach lining. By decreasing acid levels, it provides relief from symptoms such as acid-related indigestion and heartburn. Pantoprazole is commonly prescribed for the management of various acid-related disorders, including gastroesophageal reflux disease (GERD), peptic ulcers, and gastritis. Its mechanism of action offers sustained relief and healing for conditions caused by excessive stomach acid production.

Pantoprazole is used in the treatment of heartburn, gastroesophageal reflux disease (acid reflux) and peptic ulcer disease.

Diarrhea, Flatulence, Headache, Nausea, Vomiting, Dizziness, Abdominal pain, Joint pain, Injection site reaction

Pantoprazole should be taken 1 hour before a meal, preferably in the morning. It is a well-tolerated medicine and provides relief for a long time.

"Hydrochloric acid (HCl) secretion into the gastric lumen is a process regulated mainly by the H(+)/K(+)-ATPase of the proton pump, expressed in high quantities by the parietal cells of the stomach. ATPase is an enzyme on the parietal cell membrane that facilitates hydrogen and potassium exchange through the cell, which normally results in the extrusion of potassium and formation of HCl (gastric acid). Proton pump inhibitors such as pantoprazole are substituted benzimidazole derivatives, weak bases, which accumulate in the acidic space of the parietal cell before being converted in the canaliculi (small canal) of the gastric parietal cell, an acidic environment, to active sulfenamide derivatives. This active form then makes disulfide bonds with important cysteines on the gastric acid pump, inhibiting its function."

• 1. Pantoprazole may decrease the excretion rate of Abacavir which could result in a higher serum level.


• 2. The serum concentration of Pantoprazole can be increased when it is combined with Abametapir.


• 3. The metabolism of Pantoprazole can be increased when combined with Abatacept.


• 4. Pantoprazole may decrease the excretion rate of Abemaciclib which could result in a higher serum level.


• 5. The metabolism of Abrocitinib can be decreased when combined with Pantoprazole.

"Pantoprazole should be taken 1 hour before a meal, preferably in the morning. It is a well-tolerated medicine and provides relief for a long time. Some healthy tips to prevent acidity from happening: Avoid excessive intake of carbonated beverages/soft drinks, citrus juices, fried food, caffeinated beverages like tea and coffee. Avoid alcohol and smoking. Avoid eating late at night or before bedtime. Inform your doctor if you get watery diarrhea, fever or stomach pain that does not go away. Inform your doctor if you do not feel better after taking it for 14 days as you may be suffering from some other problem that needs attention."

If you have missed giving any dose of this medicine, then give it as soon as you remember. If it's already time for the next dose then skip the missed dose and follow the regular dosing schedule. Follow the dosing schedule regularly & take this medicine at regular intervals.

• 1. Oostendorp RL, van de Steeg E, van der Kruijssen CM, Beijnen JH, Kenworthy KE, Schinkel AH, Schellens JH: Organic anion-transporting polypeptide 1B1 mediates transport of Gimatecan and BNP1350 and can be inhibited by several classic ATP-binding cassette (ABC) B1 and/or ABCG2 inhibitors. Drug Metab Dispos. 2009 Apr;37(4):917-23. doi: 10.1124/dmd.108.024901. Epub 2009 Jan 12. [Article]
• 2. Chioukh R, Noel-Hudson MS, Ribes S, Fournier N, Becquemont L, Verstuyft C: Proton pump inhibitors inhibit methotrexate transport by renal basolateral organic anion transporter hOAT3. Drug Metab Dispos. 2014 Dec;42(12):2041-8. doi: 10.1124/dmd.114.058529. Epub 2014 Sep 19. [Article]