NIC BACT

Description

This antibiotic ointment is commonly prescribed for the treatment of bacterial skin infections, such as impetigo, folliculitis, and other localized infections. It works to eliminate the bacteria present on the skin, thereby preventing the infection from spreading and promoting healing.

Mupirocin is used in the treatment of bacterial infections.

Itching, Burning sensation, Stinging sensation, Pain

Clean and dry the affected area and apply the medicine at least 3 times a day. A dressing can be applied over the treated area if needed.

Mupirocin specifically and reversibly binds to bacterial isoleucyl transfer-RNA (tRNA) synthetase, which is an enzyme that promotes the conversion of isoleucine and tRNA to isoleucyl-tRNA. Inhibition of this enzyme subsequently leads to the inhibition of the bacterial protein and RNA synthesis. Mupirocin is bacteriostatic at lower concentrations but it exerts bactericidal effects with prolonged exposure, killing 90-99% of susceptible bacteria over a 24 hour period

• 1. The risk or severity of bleeding can be increased when Mupirocin is combined with Acenocoumarol.


• 2. The risk or severity of methemoglobinemia can be increased when Mupirocin is combined with Ambroxol.


• 3. The risk or severity of methemoglobinemia can be increased when Mupirocin is combined with Articaine.


• 4. The risk or severity of methemoglobinemia can be increased when Mupirocin is combined with Benzocaine.


• 5. The risk or severity of methemoglobinemia can be increased when Mupirocin is combined with Benzyl alcohol

Do not skip any doses and finish the full course of treatment even if you feel better. Take it with food, preferably at the same time everyday.

If you have missed giving any dose of this medicine, then give it as soon as you remember. If it's already time for the next dose then skip the missed dose and follow the regular dosing schedule. Follow the dosing schedule regularly & take this medicine at regular intervals.

Q. For how long do I need to use Nicbact 2% Ointment?

Use Nicbact 2% Ointment for the duration advised by your doctor. The bacteria are normally cleared from your skin within 10 days of starting the treatment. Do not use it for more than 10 days. If your skin condition does not improve within 3-5 days, see your doctor.

Q. How should I use Nicbact 2% Ointment?

Follow the directions given by your doctor carefully. Wash your hands before applying Nicbact 2% Ointment. Apply the ointment to the infected area of skin 2-3 times daily or as told by your doctor. You can cover the treated area with a dressing or leave it open as per your doctor’s advice.

• 1. Parenti MA, Hatfield SM, Leyden JJ: Mupirocin: a topical antibiotic with a unique structure and mechanism of action. Clin Pharm. 1987 Oct;6(10):761-70. [Article]
• 2. Putnam CD, Reynolds MS: Mupirocin: a new topical therapy for impetigo. J Pediatr Health Care. 1989 Jul-Aug;3(4):224-7. [Article]
• 3. Lamb YJ: Overview of the role of mupirocin. J Hosp Infect. 1991 Sep;19 Suppl B:27-30. [Article]
• 4. Pappa KA: The clinical development of mupirocin. J Am Acad Dermatol. 1990 May;22(5 Pt 1):873-9. [Article]
• 5. Poovelikunnel T, Gethin G, Humphreys H: Mupirocin resistance: clinical implications and potential alternatives for the eradication of MRSA. J Antimicrob Chemother. 2015 Oct;70(10):2681-92. doi: 10.1093/jac/dkv169. Epub 2015 Jul 3. [Article]
• 6. MUPIROCIN OINTMENT USP, 2% - DailyMed
• 7. MUPIROCIN OINTMENT - FDA Label
• 8. BACTROBAN (mupirocin) ointment, for topical use - FDA Label